Replacement of diseased or injured corneal tissue, with that from a deceased donor, can restore sight and greatly improve quality of life for many individuals.
We have led the way in evaluation of this procedure in Australia, with the establishment of the Australian Corneal Graft Registry in 1985.
Laboratory-based research also examines potential ways to extend the survival of these grafts.
Our research also looks at improving the quality of human donor corneas for corneal transplantation. The two leading causes of corneal graft survival are allograft rejection and endothelial cell failure. Animal models provide a means to better understand the causes of these complications and enable exploration of potential ways to prolong graft survival, through novel treatments.
Funding is provided by the Australian Organ and Tissue Donation Authority (DonateLife) for the operation of the ACGR, and through the Perpetual Trustee Company Ltd for project FR2013/1310: Improving the quality of human donor corneas for corneal transplantation.
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